Instituto Splendore Instituto Splendore
Procedure · Firmness and Skin Quality

Collagen Biostimulator

Injectable substances that activate the body's own natural collagen production — firmness and radiance that build up progressively, at your own pace.

1–3Sessions
30–60 daysInterval between sessions
30 daysOnset of result
Up to 6 monthsProgressive effect

How it works

Collagen biostimulators are injectable substances that activate the body's own natural collagen production, treating sagging and restoring firmness, support and radiance to the skin progressively — unlike traditional fillers, which deliver immediate volume.

The two most established biostimulators on the market have different compositions: one is made of poly-L-lactic acid, with a slower onset of action and maximum effect from the first month onward; the other is made of calcium hydroxyapatite, with improvement noticeable within the first weeks, thanks to a more viscous composition that also fills locally. The choice between them is made during the assessment consultation, considering the goal, the area and the skin characteristics of each patient.

Protocol and results

It is recommended to improve skin texture, treat sagging, soften wrinkles and expression lines and improve the contour of the face and body. The greater the degree of sagging, the more sessions may be needed to reach the desired result — generally 1 to 3, at intervals of 30 to 60 days between them.

The application is performed with very fine needles at the office, and the patient returns to daily activities the same day. Post-procedure care includes specific massages in the following days, guided during the consultation, which help distribute the product evenly and prevent the formation of nodules.

Frequently asked questions

Questions about Collagen Biostimulator

What is the difference between the available biostimulators?
They differ in composition and onset time: one has a slower, more progressive effect, with the result lasting longer; the other improves more quickly, noticeable within the first weeks. The recommendation is defined during the assessment consultation.
Are biostimulator and filler the same thing?
No. Filler delivers immediate volume with hyaluronic acid; the biostimulator activates the body's own natural collagen production, with a progressive result focused on firmness and skin quality.
How many sessions are needed?
Generally 1 to 3, at intervals of 30 to 60 days between them — the exact number depends on the degree of sagging and the goal defined during the assessment consultation.
Does applying the biostimulator hurt?
The application is performed with very fine needles and is usually well tolerated; the team may use a topical anesthetic for greater comfort depending on the area.
Do I need special care afterward?
Yes — specific massages in the following days, guided during the consultation, help distribute the product evenly and prevent the formation of nodules.
When will I see the result?
Progressively, from 30 days onward, with the effect extending and consolidating over several months as new collagen is produced.
Personalized assessment consultation

Shall we define your protocol with Collagen Biostimulator?

Book your assessment consultation with Dra. Chris Marchetti's team and discover which collagen biostimulator is most suitable for you.